{"id":9757,"date":"2024-08-13T09:57:34","date_gmt":"2024-08-13T09:57:34","guid":{"rendered":"https:\/\/sescs.es\/?page_id=9757"},"modified":"2024-08-13T09:57:34","modified_gmt":"2024-08-13T09:57:34","slug":"impactt2d-a-genomic-strategy-for-implementing-precision-medicine-in-type-2-diabetes","status":"publish","type":"page","link":"https:\/\/sescs.es\/en\/impactt2d-a-genomic-strategy-for-implementing-precision-medicine-in-type-2-diabetes\/","title":{"rendered":"ImpactT2D: A genomic strategy for implementing precision medicine in type 2 diabetes"},"content":{"rendered":"<p><strong>Full Title<\/strong>: ImpactT2D: A genomic strategy for implementing precision medicine in type 2 diabetes<\/p>\n<p><strong>Funded by<\/strong>: Instituto de Salud Carlos III (PMP21\/00069)<\/p>\n<p><strong>Grant awarded<\/strong>: \u20ac140,855.00<\/p>\n<p><strong>Duration<\/strong>: 4 years (01\/01\/2022-31\/12\/2025)<\/p>\n<p><strong>Principal Investigator<\/strong>: Ana Mar\u00eda W\u00e4gner<\/p>\n<p><strong>Associated Researchers<\/strong>: Nicol\u00e1s Martel Suarez, Bego\u00f1a Vega Guedes, Lidia Garc\u00eda P\u00e9rez, Yolanda Ramallo Fari\u00f1a, Cristina Valc\u00e1rcel Nazco, Yeray Brito Casillas, Ver\u00f3nica D\u00e1vila Batista, Ana Mar\u00eda Gonz\u00e1lez Lleo, Mar\u00eda del Carmen Valverde Tercedor, Alejandro D\u00e9niz Garc\u00eda, Dulce Hern\u00e1ndez Correa<\/p>\n<p><strong>Objectives and Methodology<\/strong><\/p>\n<p>Whole genome sequences are becoming increasingly accessible, yet more studies are needed to demonstrate their utility in common diseases like type 2 diabetes (T2D). T2D affects approximately 14% of the Spanish adult population and is a leading cause of mortality and healthcare expenditure. It is extremely heterogeneous but lacks markers to guide personalized therapeutic decisions. Polygenic risk scores (PRS) have the potential to discriminate between different mechanisms of risk for T2D. Additionally, a small group of patients harbors coding mutations that can guide clinical decisions. The DecodeDiabetes study has identified non-coding mutations shared by patients with monogenic diabetes and T2D. ImpactT2D will deploy a strategy to demonstrate the clinical applicability of genomic information in T2D.<\/p>\n<p>To this end, it will obtain complete genomes from a unique cohort of 1,000 patients with a T2D subphenotype that maximizes genetic burden. It will define partitioned PRS and rare causal variants, and use AI tools to develop stratification models. A second validation cohort will be generated with broader phenotypic criteria using genotyping panels. This cohort will be used to validate stratification models and study differences in pharmacological responses at the extremes of the polygenic spectrum. Finally, mechanisms will be developed to implement these findings into the healthcare system.<\/p>\n<p>ImpactT2D aligns with precision medicine and genomic initiatives in T2D across Spanish and international healthcare centers. It leverages a network of primary care, clinical researchers, clinical and genomic cohorts directly relevant to the project, as well as multidisciplinary expertise in AI, clinical trials, genomics, and genetics. The strategy aims to provide transformative insights for precision medicine in T2D.<\/p>\n<p><strong>Contact Person<\/strong>: Ana Mar\u00eda W\u00e4gner<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Full Title: ImpactT2D: A genomic strategy for implementing precision medicine in type 2 diabetes Funded by: Instituto de Salud Carlos &hellip; <\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[],"tags":[],"class_list":["post-9757","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ImpactT2D: A genomic strategy for implementing precision medicine in type 2 diabetes | SESCS<\/title>\n<meta name=\"description\" content=\"El Servicio de Evaluaci\u00f3n y Planificaci\u00f3n del Servicio Canario de la Salud (SESCS) es una unidad dependiente de la Dir. del Servicio Canario de la Salud en la Cons. de Sanidad del Gobierno de Canarias, constituido por investigadores economistas, epidemi\u00f3logos, psic\u00f3logos, soci\u00f3logos, antrop\u00f3logos, bi\u00f3logos, estad\u00edsticos y evaluadores de servicios sanitarios.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sescs.es\/en\/impactt2d-a-genomic-strategy-for-implementing-precision-medicine-in-type-2-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ImpactT2D: A genomic strategy for implementing precision medicine in type 2 diabetes | SESCS\" \/>\n<meta property=\"og:description\" content=\"El Servicio de Evaluaci\u00f3n y Planificaci\u00f3n del Servicio Canario de la Salud (SESCS) es una unidad dependiente de la Dir. del Servicio Canario de la Salud en la Cons. de Sanidad del Gobierno de Canarias, constituido por investigadores economistas, epidemi\u00f3logos, psic\u00f3logos, soci\u00f3logos, antrop\u00f3logos, bi\u00f3logos, estad\u00edsticos y evaluadores de servicios sanitarios.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sescs.es\/en\/impactt2d-a-genomic-strategy-for-implementing-precision-medicine-in-type-2-diabetes\/\" \/>\n<meta property=\"og:site_name\" content=\"SESCS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SESCS2018\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sescs.es\/wp-content\/uploads\/2022\/04\/Imagen-noticia-Sescs-2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"956\" \/>\n\t<meta property=\"og:image:height\" content=\"507\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@_SESCS_\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sescs.es\/en\/impactt2d-a-genomic-strategy-for-implementing-precision-medicine-in-type-2-diabetes\/\",\"url\":\"https:\/\/sescs.es\/en\/impactt2d-a-genomic-strategy-for-implementing-precision-medicine-in-type-2-diabetes\/\",\"name\":\"ImpactT2D: A genomic strategy for implementing precision medicine in type 2 diabetes | SESCS\",\"isPartOf\":{\"@id\":\"https:\/\/sescs.es\/#website\"},\"datePublished\":\"2024-08-13T09:57:34+00:00\",\"description\":\"El Servicio de Evaluaci\u00f3n y Planificaci\u00f3n del Servicio Canario de la Salud (SESCS) es una unidad dependiente de la Dir. del Servicio Canario de la Salud en la Cons. de Sanidad del Gobierno de Canarias, constituido por investigadores economistas, epidemi\u00f3logos, psic\u00f3logos, soci\u00f3logos, antrop\u00f3logos, bi\u00f3logos, estad\u00edsticos y evaluadores de servicios sanitarios.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sescs.es\/en\/impactt2d-a-genomic-strategy-for-implementing-precision-medicine-in-type-2-diabetes\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sescs.es\/#website\",\"url\":\"https:\/\/sescs.es\/\",\"name\":\"SESCS\",\"description\":\"Servicio de Evaluaci\u00f3n del Servicio Canario de Salud - 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