{"id":11838,"date":"2025-10-01T14:01:49","date_gmt":"2025-10-01T14:01:49","guid":{"rendered":"https:\/\/sescs.es\/?p=11838"},"modified":"2025-10-01T14:02:04","modified_gmt":"2025-10-01T14:02:04","slug":"quality-life-alpha1","status":"publish","type":"post","link":"https:\/\/sescs.es\/en\/quality-life-alpha1\/","title":{"rendered":"SESCS PUBLICATION: Can Quality of Life Tests Be Useful in Patients Affected by Alpha-1 Antitrypsin Deficiency?"},"content":{"rendered":"<p>Jos\u00e9 Mar\u00eda Hern\u00e1ndez-P\u00e9rez, Hassan Khadour-Khadour, Gema Romero-Romero, Miguel \u00c1ngel Garc\u00eda-Bello<\/p>\n<p><strong>ABSTRACT<\/strong><\/p>\n<p>Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that predisposes a person to certain diseases over their lifetime, mainly including lung disease (in the form of emphysema) and liver disease (liver cirrhosis). Quality of life questionnaires are instruments designed to quantify the deterioration of a patient\u2019s health.<\/p>\n<p><b>Background\/Objectives<\/b>:<\/p>\n<p>This study aimed to assess whether certain quality of life tests that are routinely used in clinical practice can be useful for patients with AATD.<\/p>\n<p><b>Methods<\/b>:<\/p>\n<p>A sample of AATD patients, with various genotypes, but with the common characteristic that they must have both altered alleles (Pi* \u2260 M), participated in the study. Different quality of life tests were used, including the COPD Assessment Test (CAT), COPD and Asthma Sleep Impact Scale, the short form of the Short Form Health Survey, and EuroQol 5 dimensions, and were related to differing clinical and functional characteristics.<\/p>\n<p><b>Results<\/b>:<\/p>\n<p>The sample was composed of 54 patients, and slightly more than half of the participants were women (57.4%), with a mean age of 51.5 \u00b1 13.7. The main genotypes were Pi*SZ (43.4%) and Pi*ZZ (34%). In patients under 65 years of age (<span class=\"html-italic\">n<\/span>\u00a0= 47), those who were actively working could walk a greater distance in the walking test, namely, 573 m (511\u2013629), compared to those who were not actively working, namely, 415.5 m (392\u2013469;\u00a0<span class=\"html-italic\">p<\/span>\u00a0&lt; 0.001). Active non-workers had a worse CAT (13.6 \u00b1 7.8 vs. 4.6 \u00b1 4.3;\u00a0<span class=\"html-italic\">p<\/span>\u00a0&lt; 0.001). In total, 80% of non-working patients had exacerbations, but only 46. 9% of those who were active, although the association did not reach statistical significance (<span class=\"html-italic\">p<\/span>\u00a0= 0.068). Having a lower score in the physical component of SF-12 was related to suffering from lung disease (46.0 \u00b1 11.4 vs. 38.4 \u00b1 11.1 (<span class=\"html-italic\">p<\/span>\u00a0= 0.026)).<\/p>\n<p><b>Conclusions<\/b>:<\/p>\n<p>Quality of life tests were able to detect differences and relate them to functional factors such as the distance covered in the walking test, being sensitive and specific in this regard.<\/p>\n<p>You can read the full article <a href=\"https:\/\/www.mdpi.com\/2077-0383\/13\/24\/7711\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jos\u00e9 Mar\u00eda Hern\u00e1ndez-P\u00e9rez, Hassan Khadour-Khadour, Gema Romero-Romero, Miguel \u00c1ngel Garc\u00eda-Bello ABSTRACT Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that &hellip; <\/p>\n","protected":false},"author":3,"featured_media":6868,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[229,105],"tags":[462,464,463,461],"class_list":["post-11838","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","category-news","tag-alpha-1-antitrypsin-deficiency","tag-asthma","tag-copd","tag-quality-of-life-assessments"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SESCS PUBLICATION: Can Quality of Life Tests Be Useful in Patients Affected by Alpha-1 Antitrypsin Deficiency? 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